[stlnative]

This explains the climb to 45,000 ft. (as someone said who ever was flying the plane could prepare for the climb) http://www.langleyflyingschool.com/Pages/Human%20Factor—Hypoxia.html

[diogenes ghost]

The climb to 45,000’ (if it even happened) means nothing. It, by itself, has no effect on hypoxia.