Well yes, but why? This is a standard air route. Why would they select one single plane to destroy?
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If such a shoot down actually would have occurred, it may most likely have been accidental. Humans screw up.
But I don’t think a “shoot down” is anything but the remotest possibility.
“Humans screw up”
Back about 1962 an F100 shot down a B52 in New Mexico. The fighter pilot was the squadron safety officer.