If there is no communication from the pilot, then something catastrophic happened. That increases the chance a bomb on board the plane may have exploded and brought it down.
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that seems to be the most likely scenario, either something blew in the plane/engine failure or in my recent reply,ground to air attack.
From Fox:
The plane’s first officer is Fariq Ab.Hamid, a 27-year-old who joined the airline in 2007. Both are Malaysians.