The GOP? Marriage law, abuse of women, slavery, were all GOP concerns, I have lost my source but even alcohol use by the Apache was a concern of the party founders.
What they were concerned with, on a state level, was entirely different than on a national level.
Slavery was a violation of “all men are created equal” and was a Federal concern.
Marriage, alcohol, and women’s rights, were being addressed at the state level.
Alcohol use was addressed by Congress, then Constitutional amendments passed were later repealed.
Marriage and medicine are handled by the several states and are not in the purview of the U.S.Constitution.