lots of people have died from .22 LR rounds. I believe many underestimate the danger of the .22 LR round. Espeicially from a rifled long gun barrel.
I have a friend who almost died from a .22LR. As it happened, he did lose his lower leg.
The great colonel Askins once said that if .22 rimfires could just about make mexican deer extinct(some question as to the veracity of that)then it’s powerful enough to kill a man. Melon shots would work nicely.