Speculation holds that ocean circulation changes resulting from the closing of a straight occupied by current day Panama started the current ice age.
http://geology.utah.gov/surveynotes/gladasked/gladice_ages.htm
Some believe reverting to the previous circulation pattern would be beneficial in the long view.
http://dissention.wordpress.com/2012/03/12/advantages-of-destroying-the-isthmus-of-panama/
Much closer to home and at a smaller scale, a similar event nearly came to pass in 1973.
Tidal currents?
And of course any “climate change” that occurred because of the change in the currents would be blamed on man made carbon dioxide.