I’ve driven 6 different F250 4x4s over 200,000 miles each.
Our family currently owns 9 F250s and F350s from an’87 up to a couple of 2013s. I live near where they make Dodge transmissions. Would own one if you gave it to me.
The only one with any major issues was one that an employee got stuck with and gunned the cold engine to about 8000rpm.