Ted Stephens of Alaska was hit with charges by a partisan prosecutor and it cost him re-election. He was convicted just a few days before the vote, only to have all the convictions thrown out. But, by then the damage (Sen. Lisa Murkowski) was done.
Scooter Libby became the focus of the deranged special prosecutor Fitzgerald and was eventually convicted of a non-sense crime of "lying to the FBI", because his recollection of a conversation was at odds with two journalists, years after the fact. Further, President George W. Bush failed to pardon him, inexplicably. (Perhaps a pissing contest with Chenney, if recent books are accurate?) Thus, this had a huge negative impact on his life. (Loss of voting rights, law license, ability to own guns, etc.)
Tom Delay was convicted, in 2011, of supposedly violating Texas election law. This is amazing when you consider the violations of FEC rules are almost routine at the Federal level and almost always result in minor "slap on the wrist" style fines. The conviction was over-turned on appeal, which is being challenged by the DA. Again, this ended his career, but was essentially a completely fabricated charge.
Very good memory you have, regarding Stephens, Libby and Delay! ...I’ve never figured out why Bush didn’t pardon Libby.