.45 jhp 230 grn Hornady backed up by 12 gauge.
I like a Ruger Vaquero, loaded with .45 LC, 250 grain Hornady XTP, w/18 grains of Alliant Powder... backed by a 12 gauge shotgun.
[At least that’s how I USED to load them before all of my guns were lost in a tragic boating incident. Now I am unable to defend myself against home invaders...]