His talent as an undiscovered liar is gone. He doesn’t really have any other talent left. Anything he does from now on, even ending Obamacare, means nothing because he can never again be trusted. He promised the people one thing if they voted for him. They did and he made certain he long knife stabbed them in the back. There is nothing that can be done to rehabilitate Rubio now. That is the price you pay for being a traitor to your country, and a liar.
The only people who believe he can be redeemed are his RINO buddies of the GOPe and they are desperately trying everything they can imagine.
My best hopes are with Ted Cruz, but politics can take odd twists and turns and thereby resurrect failed careers. Churchill, for example, was widely disliked and scorned for his many derelictions and faults, but he rejected appeasement of Nazi Germany when almost all the country and political establishment favored it. As a result, when Britain found itself at war with Hitler and determined not to make a peace treaty, Churchill was recognized as the only credible war leader. It may take a similar twist of history for Rubio to recover, but it cannot be ruled out.