IF it was possible to reduce drug abuse without sacrificing our God-given rights, I would be for prohibition. But it's NOT possible and prohibition has done NOTHING but make certain people rich at the expense of ALL our property and rights.
Just because you don't like something doesn't mean there needs to be a law against it. ALL laws have unintended consequences and the WOD probably came with the worst.
Again, entire nations are under the control of the illegal drug industry because prohibition makes these otherwise worthless chemicals more valuable than gold.
I think that we can find a way to enforce laws against child porn, drugs, counterfeiting, sex trafficking, child sex, and so on.