The template for doing so as well as some of the likely consequence is right there in South Africa, if they ever decide to do so. They’re under pressure to do it and have been for decades, another similarity. My understanding of scriptural prophecy says they will do it, and it will turn out even worse.
In retrospect, there should have been a deal to hand over most of South Africa to ANC, while making Cape Town an independent city-state (from the Republic of South Africa) with an Afrikaner majority.