Ammo has come a long way ... a good CCI 22LR today is nearly the equivalent to yesterdays .38
That being said I dropped a Deer where it stood (35 years ago) with a 22LR ... it’s placement first
TT
When I find a good 22 magnum revolver with 8 or 9 round cylinder I’m gonna make it a cc gun. For home defense, something that starts with “4” will do nicely, after I empty the SxS buckshot loads.