If he resigns in order to run, at least New York will be shut of him. But only if he loses the Presidency. If he wins, watch out. You also have to find all of his horcruxes and destroy them without him twigging, or he’ll come back, just like last time.
I never read "Clockwork Orange," so I have no idea what that means. Is it something like driving a stake through a vampire's heart?