And, the immigrant European and African populations were cut down just as bad ~ once the plague stopped the Europeans and Africans swarmed over both continents with ease since they had bulging populations back home that could relocate here and fill the gap.
Eventually something like that will happen to the Middle Eastern urban populations proving one more time why all succeeding empires in the region have brought with them peculiar beliefs and customs typical of a couple of tribes of Bedouin.
It's good to hang around the goats and sheep apparently.
Now, a good question ~ will this interrupt the flow of gas and oil? The answer is, of course, no, because the Western world has invented a successful environmental safety suit which will allow a limited number of trusted people to go in and repair the valves as needed.
Sooo... The ME has a burgeoning vermin population that will wipe them all out?
And if some plague hits it will really wipe them out?
I like it.
Historical Review: Megadrought And Megadeath In 16th Century Mexico (Hemorrhagic Fever)