Posted on 08/25/2012 10:31:56 PM PDT by null and void
As doctors battled a deadly, drug-resistant superbug at the National Institutes of Healths Clinical Center last year, they turned to an antibiotic of last resort.
But colistin, is not a fancy new creation of modern biotechnology. It was discovered in a beaker of fermenting bacteria in Japan in 1949.
That doctors have resorted to such an old, dangerous drug colistin causes kidney damage highlights the lack of new antibiotics coming out of the pharmaceutical pipeline ...
Experts point to three reasons pharmaceutical companies have pulled back from antibiotics ... There is not much money in it; inventing new antibiotics is technically challenging; and, in light of drug safety concerns, the FDA has made it difficult for companies to get new antibiotics approved.
While a new antibiotic may bring in a billion dollars over its lifetime, Shlaes said, a drug for heart disease may net $10 billion. Depression and erectile dysfunction drugs typically taken daily for years, unlike antibiotics, which are used short-term are also more profitable than antibiotics.
Shlaes said that concerns about antibiotic safety driven by deaths linked to the drug Ketek that came to light in 2006 have made the FDA reluctant to approve new antibiotics. Theyve basically made it impossible for companies to develop and market antibiotics in the U.S., he said.
Ed Cox, head of the FDAs office of microbial products, said the agency is looking at new approaches for speeding up the approval of new antibiotics, such as requiring smaller clinical studies and allowing research with patients such as those who have multiple infections.
Shlaes characterized the moves at FDA as trying to paint themselves out of a corner.
In a recent survey of infectious disease specialists, Spellberg said, 60 percent reported encountering infections resistant to every antibiotic.
(Excerpt) Read more at washingtonpost.com ...
If that doesn't work, battery acid will, but you better be ready for that because it hurts.
I've used kerosene for over 50 years and I'm still alive.
Battery acid, just a small drop on an infected cut pretty much takes the infection out.
Just have some fresh water handy to wash it off.
First time I used battery acid was by accident.
Had a cut on side of my finger and another on the end of the same finger. Went straight down the end of my finger half way through the nail. Both cuts were infected and my finger was swollen and a bright red.
Pulled a cracked battery out of a tractor. The acid from the battery soaked the bandage on my finger.
The water trough was about 100 yards away, so it burned like crap until i got to the trough to wash it off.
Next day infection, swelling, and soreness was pretty much gone.
I've dabbed acid on cuts a lot of times since then.
Hasn't killed me yet, although I do get an urge to jump start a car every now and then.
The bottom line is that the age of profligate antibiotic use is drawing to a close, and sensibly, their use in the future will likely be limited to just known pathogens in controlled situations, like hospitals. No more public use by prescription. No more prophylactic use.
However, this does not mean that we are helpless against pathogens, just that we have to adapt to how we deal with them. Here are some axioms.
1) Antibiotic resistant bacteria have become commonplace, and many or even most people already have them in their bodies in small numbers. They are kept in check by the rest of our bacterial flora, that physically deny them the space to grow. They only become dangerous when we take antibiotics that damage our normal flora, which allows the resistant bacteria to have a potentially deadly population explosion.
2) Bacteriophage viruses, that consume bacteria, have been known since 1915, and are the bulk of the viruses in the world. Unfortunately, while they will attack pathogens, the bacteria become resistant to them even faster than they do to antibiotics. So their use is only suggested in combination with antibiotics.
3) However, our own flora, in combination with our immune system, may be the best defense of all. The adult GI tract has between 300 and 1000 (or more) different types and strains of bacteria. Of these, only 30 or 40 take up almost all the space, and our immune system is interactive with them. And it is very easy to boost this colony, by consuming foods that support and enhances these bacteria.
4) But our immune system is also essential to this defense. It can be enhanced and protected to make us much more resistant to infection. Vitamin D, a hormone, does several things to strengthen our immune system and fight pathogens, both bacteria and viruses. However, it can also be weakened or dulled by arsenic, other chemicals, toxins and free radicals.
As an aside, while there are a lot of “probiotics” now sold to improve the intestinal flora, there is now a live culture yogurt drink that is especially good, having about 10 different cultures, instead of the 1-3 found in most probiotics and other yogurts.
It is called “Kefir”, and is sold as a flavored or unflavored yoghurt drink under several brands now in stores. The flavored kind, especially, is rather tasty. Often it is low fat as well.
Everyone with any real understanding of the issue knows the FDA is to blame. They're doing the same thing they did in 1984 when they almost destroyed the vaccine industry. Vaccine makers stopped making vaccines because of the constantly increasing costs associated with protecting themselves from predatory and frivolous lawsuits.
Twenty years ago, the FDA began increasing the requirements that drug companies prove new antibiotics are effective and safe, and then forced them to increase the number of participants in clinical trials. Naturally, this was all at the drug company's expense. The end result, of course, was that just like in 1984, companies got out of the antibiotic business in huge numbers.
Now that Congress has finally begun to realize that they, once again, screwed the pooch, they are offering extended patent protection, fewer regulations and tax breaks to get the antibiotic pipeline rolling again. They're only about 20 years too late. Typical government FUBAR. Even so, there is a large contingency of "conservatives" who will demonize "big pharma" for not delivering the silver bullets they demand.
I had a biochem professor who liked to tell us that the bugs would inherit the earth. Little did he know just how much government would do to help them along.
Thanks for the ping!
LOL...sorry! I should have put the sarcasm tag there. I thought you would get that.
Professional courtesy...
Back to Basics Bump
May God bless ya’ll.
Tatt
That’s why when we get sick we take herbs (and also for health maintenance).
Since we have no $ for doctors and I’m allergic to almost all drugs I’ve ever taken bar a few of them, we’re still alive at least.
Hahaha...too funny!
bfl
“LOL...sorry! I should have put the sarcasm tag there. I thought you would get that.
LOL...sorry! I should have put the sarcasm tag there. I thought you would get that. “
—
This conversation makes me want to post something sarcastic.
.
Heh, don’t let US stop you...
We might enjoy it.
/s (I think)
Please feel free to do so.
We might enjoy it.
</sarc> (maybe)
You’re Welcome, Alamo-Girl!
He’s being sarcastic.
Antibiotics have “failed to appreciate the virus’s leading role in the world” and have “shown arrogance and been dismissive, even derisive”.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.