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Stress signal causes abnormal implantation location and pregnancy loss
Journal of Biological Chemistry ^ | 2011-2-25 | Journal of Biological Chemistry

Posted on 08/21/2012 11:10:29 AM PDT by Maelstorm

Pregnancy loss is a common and painful condition for gestational women, accounting for 25-40% of total pregnancy, having become a serious social-medical issue worldwide. Animal studies and clinical investigations have indicated that the cause of many mid-term miscarriage/abnormal pregnancy has been seeded very early during the onset of embryo implantation. Epidemiological study also showed that maternal stress at early pregnancy is strongly associated with various complications during ongoing gestation. However, whether and how the process of embryo implantation is affected by environmental factors such as stress induced sympathetic activation remained elusive. Considering the mammalian uterus is an organ with extensive sympathetic innervations, the research group leads by Prof. Enkui Duan at Institute of Zoology, Chinese Academy of Sciences hypothesized that it is possible that around the time of embryo implantation, stress-induced sympathetic activation may directly affect embryo-maternal interactions through adrenergic receptors, therefore affecting the quality of ongoing pregnancy.

By using mouse model, the research group found an unexpected, transient effect of β2-Adrenoceptor (β2-AR) activation (Day4 postcoitus) in disrupting embryo spacing at implantation (without changing implantation timing), leading to substantially increased mid-term pregnancy loss. In vitro and in vivo studies demonstrated that the transient β2-AR activation abolished normal preimplantation uterine contractility, without adversely affecting blastocyst quality. The contractility inhibition is mediated by activation of cAMP-PKA pathway and accompanied with specific downregulation of lpa3, a gene previously found to be critical for uterine contraction and embryo spacing. These results recapitulated the concept that “on-site” intrauterine embryo location mediated by concerted uterine contraction is crucial for successful ongoing pregnancy.

(Excerpt) Read more at rpb.ioz.ac.cn ...


TOPICS: Culture/Society; News/Current Events; US: Missouri
KEYWORDS: akin; miscarriage; pregnancy; stress
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To: Maelstorm
Yeah, too bad the GOP shot one of their own out of the saddle in cold blood before the facts came out. Democraps always circle the wagons. Republicrats circle the firing squad.

AKIN WAS RIGHT.

21 posted on 08/21/2012 1:01:07 PM PDT by backwoods-engineer (My game is disruption. I will use lethal force --my vote-- in self-defense against Obama.)
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To: wita

“We” do? Who are “WE”?

You people HAVE to be kidding.


22 posted on 08/21/2012 1:08:45 PM PDT by EnquiringMind
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To: wita

“We” do? Who are “WE”?

You people HAVE to be kidding.


23 posted on 08/21/2012 1:08:49 PM PDT by EnquiringMind
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To: heartwood

Extreme stress can also delay ovulation, which may prevent pregnancy following the traumatic event, but allow pregnancy to happen unexpectedly somewhat later in the cycle from another procreative act. (My wife and I learned this after the fact from our fourth child).


24 posted on 08/21/2012 1:10:10 PM PDT by Hieronymus ( (It is terrible to contemplate how few politicians are hanged. --G.K. Chesterton))
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To: backwoods-engineer

maybe not...
http://www.freerepublic.com/focus/f-news/2921209/posts


25 posted on 08/21/2012 1:10:14 PM PDT by chaos_5
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To: LearsFool

Uh, the PROBABILITY of pregnancy during a rape may be somewhat lower, but it’s nowhere near ZERO. anyone who thinks pregnancy after rape doesn’t happen is an idiot.


26 posted on 08/21/2012 1:41:42 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: LearsFool

Uh, the PROBABILITY of pregnancy during a rape may be somewhat lower, but it’s nowhere near ZERO. anyone who thinks pregnancy after rape doesn’t happen is an idiot.


27 posted on 08/21/2012 1:41:42 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: Kozak

What’s your point?


28 posted on 08/21/2012 1:47:07 PM PDT by LearsFool ("Thou shouldst not have been old, till thou hadst been wise.")
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To: Maelstorm

I am not a mouse.


29 posted on 08/21/2012 1:47:26 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: Kozak

I’ve read several pro-life articles about rape victims who decided to keep the resulting offspring. The above article doesn’t establish a 100% scenario of protection for the victim. Only idiots are pushing this theme.


30 posted on 08/21/2012 1:48:22 PM PDT by aimhigh
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To: backwoods-engineer
Maybe in your mind he WAS right but now he must be wrong because he recanted what he said and apologized for it.
31 posted on 08/21/2012 1:50:39 PM PDT by DManA
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To: EnquiringMind
This is a horrific insult to any women who has ever been impregnated by a rapist. Basically, you’re saying, just as that nitwit Akin said: if a women reports that she was raped and is then impregnated, it wasn’t rape after all? She enjoyed it? SHe asked for it?

you really need to pay attention to what was said. If a woman experiences an actual rape, there are times when her body will react differently and she will suffer a spontaneous abortion (miscarriage) or she will not be impregnated at all.

nowhere does anyone say that she cannot become pregnant, we all know that she can. That having been said, do we then execute the child for the crime of its father???

sheesh

32 posted on 08/21/2012 2:05:38 PM PDT by terycarl
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To: terycarl

A woman, or a Chinese mouse?


33 posted on 08/21/2012 2:17:03 PM PDT by EnquiringMind
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To: Maelstorm
For many reasons, this post is the height of freeper scientific and statistical ignorance.

It reminds me why there are only a very few Freepers I trust with science. Also one of the reasons the Global Warming threads here are mostly a joke.

Its not even worth getting into it here, I give up.

34 posted on 08/21/2012 2:22:25 PM PDT by Paradox (I want Obama defeated. Period.)
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To: Maelstorm

That isn’t “prevention of pregnancy”. It’s “messes up the pregnancy and causes a spontaneous abortion”.

If the argument is that we don’t need to allow abortion for rape victims, because if they are stressed out and sad enough long enough, they will self-abort, then I guess you have us there.

Oddly, there are many living people who were conceived in rape, where I guess their mothers didn’t stress enough.


35 posted on 08/21/2012 2:24:42 PM PDT by CharlesWayneCT
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To: EnquiringMind

We, refers to folks familiar with the research and statistics on completed rapes and resulting pregnancies, which you may not be interested in.


36 posted on 08/21/2012 2:30:29 PM PDT by wita
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To: Hillary'sMoralVoid

There are many statistics. Of course, you can’t find an easy apples-to-apples comparison. For example, overall, you are slightly more likely to end up pregnant from a consumated rape than from a consensual consumated sexual encounter.

But that is in part because protection is more often used by those in consensual sexual relationships. And because the statistics are years old, and don’t take into account the recent practice of using post-rape abortion morning-after pills to stop pregnancy resulting from rape.

It is clear that stress has some impact on the ability to get pregnant. While some here were laughing about that yesterday, most of us who opposed Akin’s comments weren’t making that mistake. The problem is that stress does not “greatly reduce” pregnancy. Even Wilke, cited here yesterday in support of the concept, chose to believe it had a 50% reductive effect. Large, but not orders of magnitude.

Unfortunately, that is somewhat mitigated by the virtual certainty that the rapist isn’t using condoms, and the good chance that the woman wasn’t prepared and didn’t therefore have her own protection deployed. And of course, the man wasn’t trying to choose times when the woman was less likely to get pregnant.

Of course, the fact that we are even TALKING about this is the reason many of us were upset at Akin’s comments. It was an absurd choice of argument, it muddied the waters for the legitimate pro-life argument, and it distracted from the real issues. It allowed the liberals to smear all republicans with the false charge that we don’t think women can get pregnant from rape.

It also fed right into the “war on women” meme, with his use of “legitimate rape”. It reminded people of Ryan’s vote for the “forcible rape” bill — which actually can be explained, but is again a distraction and hurts us with women.

If we are going to argue about abortion, let’s keep it simple — abortion is wrong because it kills human beings, and we don’t kill innocent people to fix criminal actions.


37 posted on 08/21/2012 2:35:19 PM PDT by CharlesWayneCT
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To: Kozak

anyone who thinks pregnancy after rape doesn’t happen is an idiot.

Just who has been suggesting such? The suggestion that it happens frequently is another idiotic suggestion, and I know you aren’t suggesting such.


38 posted on 08/21/2012 2:35:30 PM PDT by wita
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To: Paradox

Its not even worth getting into it here, I give up.

...and I contend that based on your home page it is incumbent on you to never give up, having come from the dark side into the light. There are those listening and watching for wisdom if it proves to be.


39 posted on 08/21/2012 2:42:59 PM PDT by wita
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To: LearsFool

The point is Akin is an idiot. Raped women do get pregnant.


40 posted on 08/21/2012 3:11:22 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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