Grease-soaked cracker crumbs? Try lining your baking pan with foil, place a cake rack on it and then place your meat loaf on it and bake. You can use a layer pan for a small meatloaf. The fat will drip thru to the bottom of the pan. The fat will harden as it cools. Wrap the foil up and throw it in the trash. I keep it in the freezer until trash day.
Wow - I do nearly the same thing, except I wrap the foil up and throw it in the mail with one of those postage-paid envelopes from some group I don’t like. At least that way it doesn’t go to a local landfill :).
Better yet, skip the pan entirely and make a free-form meat loaf. Baking the loaf on a rimmed baking sheet allows the fat and juices to drain and exposes more surface area for a better crust.