230 grains of lead in the brain will do that.
They used to call it, “Kremlin Flu”
From the 2011 Tyrant's Desk Reference (the 2012 edition isn't out yet).
KALASNI KOFF (excedrin headachium)
Description: Disloyalty eliminator. When properly administered, Kalasni Koff is effective 100% of the time. Judicial use of Kalasni Koff not only eliminates disloyalty in that subject, but suppresses expressions of disloyalty in other members of the community in which it is used.
Indications and Usage: Kalasni Koff is indicated where confidence has been lost in the faithfulness of an underlying. It has also proven effective in the symptomatic elimination of enemies, real or imagined.
Dosing and Administration Kalasni Koff is administered via a reusable applicator ("AK-47"), which comes with a refillable product carrier ("magazine"), which holds 20 individual doses ("cartridge"), each of 7.5 grams of pb coated with 0.5 grams of cu. Kalasni Koff is most effective when administered intercephaly, but can be effective in any vital organ, especially when given in multiple doses.
Contraindications: Kalasni Koff should not be administered to underlings of doubtful loyalty, except by another underling of undoubted loyalty. There are reported cases of disloyal underlings refusing to administer Kalasni Koff as prescribed, and instead administering it to the prescriber.
Adverse Reactions: Widespread administration of Kalasni Koff may actually have the effect of increasing disloyalty -- not in those to whom it has been properly administered, but in the balance of the population. Prescribers are cautioned that the "sweet spot" between insufficient and excessive use of Kalasni Koff will vary from country to country. Prescribers should vigilantly monitor their subjects, and adjust the administration of Kalasni Koff appropriately.