Well despite Brown's election, the Democrats found a way to cram Obamacare down our throats anyway, which led to the huge GOP victories later that year in the congressional mid-terms. Many elected officials who supported Obamacare were driven from office.
The Tea Party movement continued on. Christie's win in New Jersey. Walker's win in Wisconsin. Then a Republican (Bob Turner) won Weiner's seat in Brooklyn/Queens - unheard of!
So if "conservative anger" is hitting stratospheric levels, once can only imagine what this November is going to bring.
There are around 14 million self employed people in the US. They are not stupid. Add in their families and that is a pretty decent sized voting block.
Obama has lost probably 90% of their votes with the sword of obamacare taxes hanging over them.