I never met a person who wanted to be shot, with a .308 or a .22.
Sure a .22 doesn’t have the range or power of the larger calibers. It will certainly get peoples attention though.
Yeppers had an argument with a friend about this same issue he told me his bigger rifle was superior and I couldn't expect to deal with such a threat even if he gave me 5 shots to my one.
I asked him If I shot him once in the head with a 22 how effective would his next shot be with his sparky 308?
He just mumbled.