When the NB-36 flew, there was a C-119 chase plane with a group of fully armed paratroops. Should the NB-36 crash, they were to jump at the crash site to secure the nuclear material until authorities and decontamination teams arrived.
What killed the nuclear bomber was the stark fact that a crash would spread radioactive materials over a large area and require tons of remedial work. The nuclear bomber was canceled. The same thing applies to a nuclear powered drone.
I recall reading about the possibility of nuclear-powered command & control planes also. I don’t know if that idea ever made it to anything you could even call a planning stage.