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Well, we know an autopsy has been performed, so if there were any substances such as you suggest present, the police know about it. However, I think you are making a few assumptions here.

He was clearly much bigger than Zimmerman and it appears from the police data that Martin was the aggressor.

The police report lists Martin as 6'0" 160 pounds. This is likely only an estimate, but still indicates a young man who does not appear "bulked up." Zimmerman is listed at 5'9" and no weight entered. That's only three inches shorter than Martin.

There is only witness testimony to the fact that Martin appeared to be prevailing in the fight immediately before the shooting. There is no evidence I have seen (other than Zimmerman's account) that Martin was "the aggressor," and I think it is important to keep that in mind.

Nobody disputes that Martin was in the neighborhood legally, and was not engaged in any criminal acts when this chain of events began. It is entirely possible that at the time the witness saw the fight, both young men believed they were fighting for their lives.

By itself, that would not necessarily invalidate Zimmerman's claim of self-defense. Martin does not have to be a bad guy for Zimmerman to have felt threatened. It is quite clear that both of them had the opportunity to avoid a fight by simply talking to each other, and it is really tragic that they did not.