>> I guess you could alternate rounds, with the .410 first.
Sure — but what .410 load?
If you’re going with a coarse shot load (I prefer #4 for around the place), the perp better be close, literally in your face, or the shot will spread to where it’s useless.
Anything finer than #4 may be OK for smallish reptiles, but utterly useless for 2-legged snakes.
And if you’re going to load .410 buckshot, you might as well just have a .45LC in that slot instead. Significantly more punch and not THAT many fewer projectiles. :-)
When it’s laying around, I keep my Judge loaded with .45LC hollowpoint as a backup “defense” weapon. When I take it out around the place, #4 shot.
Like I said, I find it a lot of fun to shoot (if a bit spendy — priced .45LC lately?) but if you want a serious personal defense weapon I’d look elsewhere. Just my 2c
Ammo .410 Bore Federal Premium Personal Defense 3” 000 Buck 5 Pellets 960 fps 20 Round Box
http://www.cheaperthandirt.com/60311874-1.html
Works well in The Judge or Mossberg HS-410, plug removed
.
Other size shot and loads are available.
Good indoors and speaking range!