A grazing hit in the head with a .45 ACP is not going to drop the perp.
Generally, with a .45 to the leg alone, one is not going to run or flee anywhere, and will likely drop where they stand. I would imagine even a glancing strike to the forehead with the same round, would be like getting hit in the head with 5 pound hammer.
Please DO NOT count on this happening.
Seriously.
The defender in this case fired "six or seven" shots, and achieved a forehead hit (certainly glancing, a solid forehead hit with a 9mm would decorate the opposite wall with brains) and leg hit. What happened to the other four or five shots?
They missed!
This is not a "minor caliber" (what a silly term!) problem, it's a poor marksmanship problem.