States rights is simply not an exciting campaign slogan or philosophy. I also think it's a very poor plan for success of the country. We are the UNITED states and we don't gain by seceding from each other 50 different ways. We should be looking to implement good, conservative policy on the federal level where we can. What good is shutting down the EPA if every state is then allowed to enact their own environmental regulations? California for instance would do everything the EPA does and more. There comes a point when states are no longer the laboratories on a given issue and when conclusions from their experiments should be drawn and applied to the country on the federal level. The reality is that the world and the country is a far, far smaller place than it ever was before. The things each state does almost invariably affects other states, hence we should seek to have consistent federal laws across the board.
I would say your argument directly contradicts the Constitution and that somehow today things are too different for those ancient texts to apply. I think they are timeless.
And businesses and workers and their money and taxable dollars will leave the state -- last count I read it was 1,000,000 jobs lost in California -- many of those where picked up in the Texas "laboratory.