Last Spring, I took a three day Advanced Pistol Operator class and shot my 226ST in 9mm and consumed ~1,700 rounds. This one couple were shooting a G22 and G23. At the end of the first day, their fingers were taped up. They've since moved on to 1911s and Glock 17s and 19s.
I can see taping the web of your dominant hand between thumb and forefinger - the glock frame rubs me bad there after 500 rounds or so. But I've done courses with my glock 29 10mm with no more significant soreness than my glock 26, glock 23, glock 21, or glock 34. And the 1911 can wear on the skin just as easily.
First he said there was something wrong with the gun, then there was something wrong with the mags, then there was something wrong with the ammo.
I shot it, no problem.
Didn't matter what ammo I used everything from 230gr hardball to 155SWC.
Didn't matter if I used his $35 mags or my $5 mags, no problem.
He was scared of the .45 so he limp wristed. Jam every time.
If that wasn't bad enough, should have seen his group with the 7mm mag he bought as a FIRST gun.
60 rounds and I don't think he hit the target with half after the first three.