If you're talking about fusing two deuterium atoms into a helium atom, then I would agree with that. Even a 5MeV alpha particle greatly exceeds typical chemical bonds at just several eV.
Kevmo also said: "So anyways, let’s compare the price of extracting nuclear energy from a gallon of oil versus a gallon of seawater. Surely the seawater is easier to obtain?"
And it's hard to argue that seawater is not so readily available that its price would always be lower than oil. Though I have never studied the corrosive effects of seawater on pipes, it can probably be transported at much less than 93 dollars per barrel.
As for comparing the price of extracting nuclear energy from either a gallon of oil or a gallon of seawater, I'm not aware of a process that can do either.
There's a process that turns deuterium into some serious doggone energy ~ it's a favorite weapon, and tunable to boot!