My carry gun is a S&W stainless .357 Model 641. I tried shooting a .380 a couple of years ago, found that it tended to jam, the magazine was difficult to load, and the slide nicked my left thumb on the way back, a problem I never had with the slide on my Beretta .40. In short, I vastly prefer the hammerless S&W as a carry gun over a .380, even though the S&W only has five shots.
A very nice gun which I've been temped to buy myself, and an excellent choice for CC. I also used to carry a .380 due to the compact size, but found that it sometimes had feed issues with JHP ammo, and also a surprising amount of felt recoil which caused the flange above its grip to bite into the webbing between my thumb and forefinger.
I traded it in for a nice compact .45 (Taurus Millennium; 10+1 double stack mag) which fits my hand better and has considerably less recoil even given the larger round.