Well a defective baby can never have a meaningful life... /S
Actually, I think it’s up to the creativity of the parents to make the most of what God gives them. Like the story of the talents...
As far as the potential of a baby born with one limb, check out this inspirational video....
http://www.youtube.com/watch?v=Gc4HGQHgeFE&NR=1
Thank you for sharing this video, It was great.