If you aren't aware of the regulatory burden (and regulatory and tax uncertainty) and high tax rates on American businesses, I wouldn't begin to know how to bring you up to speed.
With regard to regulations on oil and gas exploration and development, I refer you to the EPA and, more specifically, what has happened in the Gulf since the BP spill (i.e. a moratorium on drilling for all intents and purposes).
As to the tax code, there needs to be a complete destruction of the existing code. It is the convoluted and outdated product of lobbyists and lawyers and payoff's made by congressmen to their supporters and has a hugely depressing effect on American business (not to mention the massive cost of implementation and collection). At this point, the Fair Tax would be an infinite improvement (but I would be open to any number of effective replacements).
And strangely, these are just a few improvements off the top of anyone's head. There are millions of things that need to be improved to make America a business-friendly environment again.
What do you recommend?
You should run for president. You have all the talking points down.