I think it's pretty obvious.
Duh! So ... why try to invent constitutional fig-leaves to cover its naked power grabbing? Why pretend that the interstate commerce clause authorizes controlling "substances"? Why not simply recognize that neither the Congress, nor the courts, nor the executive are granted any such authority? Why not simply recognize that they have baldly seized the power to do it, and nobody is in any position to say them "nay"?
You're quoting the anti-federalists, who more or less predicted that outcome. Why not say "they were right"?