Yes indeed! Size MATTERS. However, hydraulic shock transfer from rounds such as the .357 Mag and .357 Sig can also tear major vessels, whereas the (comparatively) slow moving .45 ACP is less apt to do this.
I get a chuckle out of the fact that people even compare anything nowadays to a handgun and it's cartridge first devised/manufactured over one hundred years ago and remains largely unchanged today... 1911 .45ACP. How cool is that? :-)
heheheh...Im sure that the individual being shot, and his particular parts inventory, has a *perfect* load in mass vs velocity...
but until i begin using dimes for rapid fire drills, and hittin em 100%, i'll stick with a lil more diameter vs a few more fps...8^}
im bettin in another hundred yrs we'll still be comparin .45 to all others...