Just to put a different slant on this and possibly amuse you. In the last 100 years our large corporations have expanded into every state and into other nations. They have a global reach. Much of this is due to modern communications which get tighter and faster every year. Much is due to ease of modern transport to move what they produce.
Think of the Federal Government as a very large and competing corporation. Why would it not want the same rights to get involved in every US state the way Toyota or Proctor&Gamble does. Today we have a shrinking economic pie so the dollars and resources the FedGov Corporation can acquire means less dollars and resources for the private sector corporations
Under that basic premise of a constitutional republic with a national government of limited, enumerated powers it should be irrelevant what they want.
Of course the politicians and bureaucrats in Washington want more power and authority. That is their livlihood. What's important is to realize that they want it, and will use any available means to get it. Consvervative political activism means actively opposing their attempts to assume power and authority that were not legitimately granted to them by States, either in the Constitution proper, or by amendment.