They aren't side-effects, they're the point: nothing less than the unholy grail of evil - the final erasure of conscience combined with a weeping desperation to obey.
Well, if Temperance Ax-Lady Carrie Nation and her blowhard man-at-swarms William Jennings Bryan were still with us today, they would wholeheartedly agree. And there is indeed to all sane and more moderate temperaments who look into the widespread use of these drugs some truth to be found in being inclined towards Madame Ax-wielder and her Grand PooBah in this matter.