You might want to do some research before sounding off. Check out this timeline on the history of opium, which was a well-known drug at the time.
And which was not widely used in America in the 1700's. Which is exactly the point I made.
Refined drugs (like cocaine and heroin) had not been developed yet.
"Natural" drugs (like the marijuana example I used as well as opium) simply were not widely used at the time of the founding. Opium wasn't regulated for the same reason bamboo wasn't regulated, it didn't exist in any significant degree in early America.