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To: kevkrom

Your words are encouraging for my daughter. She was diagnosed 6 months ago at age 11. Overall her symptoms are mild but she has still missed lots of school this year over mysterious ailments.

I am not sure about your meaning of “other auto-immune” indicators. Are there new drugs being developed that build on this drug?


7 posted on 03/10/2011 6:53:38 AM PST by businessprofessor
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To: businessprofessor
Belumilab (Benlysta) was originally developed to treat rheumatoid arthritis -- SLE lupus was a similar indication, and proved far easier to get approval via an FDA fast-track.

Basically, there are a whole class of autoimmune disorders that are linked with excessive B-cell production. Belumilab should be able to help with many of them, as it is a B-cell inhibitor.

From Human Genome Science's web page on Benlysta:

HGS and GSK are also examining a range of potential additional indications for BENLYSTA that might be explored in Phase 2 clinical trials, including vasculitis and post-renal transplant. In addition, a number of small proof-of-concept studies are already ongoing or imminent in Sjögren’s syndrome, Waldenstrom’s disease, pre-transplant and idiopathic thrombocytopenic purpura (ITP).
Not mentioned there, but I'm sure still in the works, is probably RA as well. I've also heard conjecture that some forms of Chron's might be treatable as well, but I can't recall how well founded that was.
8 posted on 03/10/2011 7:03:53 AM PST by kevkrom (De-fund Obamacare in 2011, repeal in 2013!)
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