I feel that the 1911 is the finest combat pistol ever designed, which I also feel is a limitation for me. A 1911 would not be my first choice for self-defense, as I feel it is a combat weapon. Speaking strictly for myself, I'm more comfortable with a revolver in this situation. And I've got the perfect one for me: A S&W 625-5 (with a combat action job by Ron Power) in .45ACP, using full moon clips.
Speaking purely for myself, I'm just more comfortable with a revolver for that use.
Mark