I have always thought he went for the Main Chance and grabbed the Gold Ring. Did some good things but layed the ground work for future destruction of the Republic.
Thug politics go back thousands of years, but the organizational skills Burr brought to Tammany Hall let the Hall pretty much run NYC politics for close to 100 years.
On the other hand, Burr set a lot of the Senatorial protocol that continues to this day. When Burr stepped down at the end of his term and gave his farewell speech to the Senate many members were in tears.
Hamilton was practically begging Burr to kill him and Burr obliged.