Doubtful. Palin’s backfired attempt to take out Murkowski may be a reason Palin doesn’t make it to the White House.
Palin’s attempt did Not exactly backfire, it was Miller who blew it by underestimating murky, and her devious machinations. Also, I don’t think she will pose sufficient threat to derail the POTUS bid but she is going to be a pest throughout the campaign.