.22 can cause suprising damage to a human body.
I can tell you this, I’d be ducking and running if someone was shooting a 22 at me.
I have a Sturm Ruger Mk 2 w/ the stainless steel “bull barrel”. I had some questions about the effectiveness as a home defensive weapon. A local shooter told me that with that gun I could barrage the assailant with a narrow cluster in a short amount of time. A number of .22 LR’s hitting within a second will do a lot of damage.
Fortunately I have not had to fire the gun in defense. There was one instance where someone was trying to break in by working open the bedroom window. The blinds were down so he could not see me. He did however hear me chamber a round. Next thing I heard was feet - getting the hey outathere.