[neverdem]

Uh, which part ~ isn't Avandia merely a one shot pill replacing the other medications ~ creating what is supposedly a more controllable flow of both?

No, there are combo oral diabetes meds, but Avandia isn't one of them. Avandamet is a combo of Avandia and metformin, i.e. Glucophage. That's why I linked the mechanisms of action for the thiazolidinediones and metformin. They are completely different.

Or do you dispute how Glipizide convinces the beta cells to yield more insulin?

No

An inlaw using both Glipizide and Glucophage encountered instant congestive heart problems with the very first use of Avandia.

Read the JAMA editorial, "Rosiglitazone and the Case for Safety Over Certainty," that I linked upthread. The gamma subtype of peroxisome proliferator-activated receptors are expressed in the nephrons of the kidney causing retention of sodium and water.

[muawiyah]

Thinking of "metaglip" ~ prescribed frequently along with Avandia.

Obviously Avandia has it's own troublemaking potential.