The major complaint against aspartame is that the by-products, while ‘natural’ build up in the body because the clearance mechanisms do not adequately handle it.
What percent of the population is at some point in their lives likely to inadequately clear the break-down products of aspartame. taken in as aspartame and not by some analogy to the components considered separately?
It may be that the essential amino acids have to be consumed in a balanced mixture — that makes some sense from a usage standpoint, as the component acids used in pairings in such vital products of metabolism as DNA and RNA, and others.
What are the by-products?
Interesting. You'd think we would have heard more about it being a major complaint and all. What "by-products" are you referring to and why wouldn't the liver be able to clear them just like the same amino acids and methanol from natural sources?
What percent of the population is at some point in their lives likely to inadequately clear the break-down products of aspartame
First, you're going to have to establish what you mean by break-down products? It appears that you're making an assumption that the components of aspartame create a "build up" of "by-products" while phenylalanine, aspartic acid and methanol from natural sources do not. Sounds like quite a story to me but I'll reserve judgment until you define your terms better.
It may be that the essential amino acids have to be consumed in a balanced mixture.
If you want a complete protein they do. In the case of aspartame, your gut breaks down aspartame into the individual amino acids before they are cleared by the liver. Your gut also breaks down long chains of amino acids into individual amino acids before they are absorbed and cleared by the liver. There are some small peptides that don't break down but most are individual.