[LibertarianInExile]

"If a state were free to nullify federal laws within its borders, or, by logical extension, to secede from the union altogether, that would pretty much spell the end of federalism in favor of a loose, and not very durable, confederation of states. Is that really what we want?"

30 states seem to think so, these days.

"A lot of blood was shed 1861-65 to determine whether this would be the choice. The outcome seems to have been that federal problems need to be resolved at the federal level."

Actually, more pragmatically, the outcome seems to have been that any effect the 10th amendment might have originally had has been entirely superseded by whoever has the best ability to force their viewpoint on the group that differs. That means that, very likely, even though 3/5ths of the states may have legislatively disagreed, it doesn't make any real difference to a "federal" government gone wild.

[Genoa]

The Constitution contains mechanisms (a free press, elections, and the federal courts) to address the situation we’re in. Let’s make the best possible use of them.

[Genoa]

Not just a free press, but the whole Bill of Rights.