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There is also no question that our biologically generated estrone, estrial, estradial, and it metabolites have varying degrees of “strength”, if I may use that term. The same is true of phthalates and phytoestrogens such as soy. Neither of the latter substances come close to having the same kind of kind of effects on the human body as the former.

I did some research on the internet today about the relative effects of estrogens, phytoestrogens, and xenoestogens like BPA. It has been shown that BPA can affect some cells in part-per-trillion (picomolar) concentrations. This paper looked at the effects on cells of low concentrations of various estrogen-like substances. As shown in the following graphs from this study, at nanomolar concentrations, BPA can even have a stronger effect than estradiol:

When someone attempts to use such words as “estrogen-like compounds”, “estrogen disruptors” and the phrase “There is no question that hormonal compounds can have effects at extremely low concentrations” alarm bells go off in my head. It tells me that they have no clue as to what they are talking about. It also tells me that they have an agenda which has no basis in scientific fact

This article describes the science and history behind this new work.

I appreciate your follow up, but this means nothing. You have a scientist who had a theory in the 80’s and came to believe that it was true. She has spent 30 years trying to develop the technology to prove her theory. She still hasn’t. She has found that these chemicals can increase calcium activity intracellular via a voltage gated calcium channel. This is turn stimulates prolactin activity. This is not the only response the cell has to estrogen. It is does not take into account the numerous messanger systems that exist in the cell that can be stimulated by estrogen. It doesn’t take into account the very thing she had trouble with in the beginning, and that is the effects of XEs on the nuclear membrane. She cannot, by the very of the nature of her experiments, even square her theory with how the body handles the detoxification of endogenous and xeno estrogens. Detoxification of estrogen by the liver requires pretty decent nutrition. The removal of conjugated estrogens thru the feces requires a pretty good functioning colon. Without these there can be a problem.

She said herself “We looked at these data and said these things are just as potent as physiological estrogens like estradiol if you look at these mechanisms,”....looking at a single mechanism, or pathway that proves her point when there are a multitude of unanswered questons. She is a typical scientist in the Rachel Carson mode....reach a conclusion first and prove it second.