I remember in a documentary film about the bombing of the Baghdad reactor that the Israeli F-16s were so loaded down with fuel and two large bombs apiece, that they used virtually the entire runway just to take off with little to spare.
Given the greater distance to Iran, the F-15I, and presumably the F-16I, would shed a lot of weight as well as their drop tanks, before entering hostile airspace.
Too bad Israel doesn't have and B-1Bs. Would make things a bit easier.