South Carolina escalated to secession, which prompted Jackson to get the Force Bill through Congress, which authorized him to make war on South Carolina to retrieve it from a state of rebellion.
Nullification is deemed unconstitutional, a casualty of both Jackson and Lincoln. I doubt the Supreme Court would suddenly ditch 175 years of jurisprudence to allow a state to nullify.
They are taking them to court to fight them on the unfunded mandates and forcing individuals to buy health insurance. They are fighting this under the commerce clause.