Gee, where does it say in the US Constitution that the Federal government can tell people to buy medical insurance?
Oh, that's right, it's not there...there.
It doesn't, which is why I don't expect the bill to make it past the Supreme Court. But unless you've never read the Constitution past Article V, which is certainly a possibility, then you'd have to understand that nullification by the states isn't allowed.
Congress will allege that the Interstate Commerce Clause covers this via the Supreme Court's decision in Wickard v. Filburn.
As to whether the current Supreme Court will accept that argument remains to be seen.