Yes you can, constitutionally and legally — if you use honest Constitutional lawyers and legislators.
You cannot nullify a law passed under the Constitution. Not legally. Not Constitutionally. If you don't like it then leave the Union. That CAN be done both Constitutionally and legally.
I’m sure this is a captain obvious statement, but, it seems plain to me that the states not only have the Constitutional right, but the duty to refuse to obey un-Constitutional laws or actions taken by the federal government. This is not secession. It is not required.
I find the situation similar to being given an order in the military that violates the military code of conduct. The soldier is not required to follow that kind of order. He/she may get into lots of trouble and have to defend themselves in court, but they do not have to be “out of the military” in order to refuse to obey.
The question will remain - does the particular state refusing to follow a specific federal law on the basis of nullification have the political and moral will to follow it through to the end? I hope the answer is “yes”.