This is a foregone conclusion. Hillary will resign at the end of 2010. In 2011 she’ll start criticizing him publicly. In 2012 she’ll run. Even the Clintons were astonished at how the Obama gangsters threw her aside in 2008.
I agree on the resignation. But if she's running in 2012, it will have to be over a public disagreement on serious matter of foreign policy -- I predict something to do with Israel, but Iran might work as well.